Medication Reconciliation Failure Led to Concurrent Anticoagulant and Antiplatelet Use
Summary
The facility failed to ensure a resident’s hospital discharge medication orders were accurately reconciled, transcribed, and verified on readmission. The resident had diagnoses including atherosclerotic heart disease and peripheral vascular disease, and the care plan addressed anemia with directions to give medications as ordered and monitor for side effects and effectiveness. The hospital discharge paperwork directed the facility to discontinue Clopidogrel 75 mg and Aspirin 81 mg and start Apixaban 5 mg twice daily, but the physician orders entered into the facility record included Apixaban without discontinuation orders for Clopidogrel and Aspirin. The medication administration record showed the resident received Aspirin for three doses and Clopidogrel for two doses after those medications should have been discontinued, while also receiving Apixaban as ordered. The electronic medical record generated an order note warning of potential drug interactions between Apixaban and both Aspirin and Clopidogrel, but the alert was not recognized or addressed by the readmitting nurse. The required secondary verification by the night supervisor was also not completed, and the facility’s documentation and interviews confirmed that the readmission orders were not reconciled correctly. During the weekend after readmission, the resident received all three medications concurrently. The nurse’s note documented vomiting dark brown material, active rectal bleeding, small to moderate rectal bleeding with small clots, sleepiness, intermittent nausea, and a blood pressure of 96/54, after which the resident was sent to the ED for evaluation. The medical director identified the event as a significant medication error, and facility leadership confirmed that the discontinued medications had not been removed from the active profile and that the readmission verification process was not followed.
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