Medication Reconciliation Failure Leads to Tacrolimus Overdose
Summary
The deficiency involves the facility’s failure to ensure that medication orders were accurately reconciled and transcribed upon a resident’s readmission, resulting in a significant dosing error. The resident, who had a history of kidney transplant and was care planned as being at risk for impaired kidney function and transplant-related complications, had been receiving Envarsus XR (Tacrolimus) 4 mg, one tablet daily prior to a hospital transfer. After a six-day hospitalization for abnormal lab values, the resident was readmitted with a hospital W-10 order for Tacrolimus XR 24-hour tablets, six 1 mg tablets daily for a total daily dose of 6 mg. An APRN note documented that admission orders and the hospital discharge summary were reviewed, and medication reconciliation was initiated, including Tacrolimus XR 6 mg by mouth daily. When entering the readmission orders into the EMR, RN #1 used the resident’s prior EMR medication list as a starting point and attempted to reconcile it with the hospital W-10. RN #1 changed the number of Tacrolimus tablets from one to six but failed to change the tablet strength from 4 mg to 1 mg, resulting in an EMR order for Envarsus XR 4 mg, six tablets once daily (a total of 24 mg instead of the intended 6 mg). RN #1 later stated she did not realize the tablet strengths were different and that she must have misread the tablet strength on the W-10, focusing only on changing the number of tablets. The incorrect order remained active in the EMR and matched a medication already available on the unit from the prior admission. The facility’s double-check system for new admissions and readmissions was not followed as intended. The DON reported that the process required a supervisor to review the W-10 with the APRN/MD and enter the orders, followed by a second supervisor performing a repeat reconciliation to verify accuracy. RN #1 entered the orders, but RN #2 did not complete the second reconciliation, reportedly due to being busy with other incidents. LPN #1 administered the Tacrolimus dose as it appeared in the EMR, stating that she relied on the fact that two supervisors had reconciled the orders and that the medication was available in the cart, and therefore did not question the dose. As a result, the resident received 24 mg of Tacrolimus instead of the ordered 6 mg before the error was identified through a pharmacy medication review.
Penalty
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