Significant Valacyclovir Dosing Error in Resident With ESRD
Summary
The facility failed to ensure a resident was free from a significant medication error when Resident 7, who had end stage renal disease and was dependent on hemodialysis, was ordered valacyclovir 1 gram three times daily for shingles. The telehealth nurse practitioner entered the full-dose order after a video visit, and the electronic health record generated severe drug-to-condition interaction alerts related to chronic kidney disease stage 5 and the need for extreme caution, but the order was still acknowledged and transcribed. The record also showed the resident had ESRD and kidney function concerns that would have required dose reduction based on renal function. After starting valacyclovir, Resident 7 developed new confusion, anxiety, insomnia, giggling, and hallucinations. A second telehealth call documented that she seemed "drunk" and had an onset of confusion that was not baseline behavior, and she was given hydroxyzine and Benadryl for insomnia and anxiety. The resident continued to worsen, with nursing notes describing confusion, nonsensical speech, and visual hallucinations such as seeing colors and stripes on the walls. STAT labs were ordered, but before they were obtained at the facility, the resident's daughter requested transfer to the hospital because of the delay. The resident received five doses of valacyclovir before refusing the sixth dose, and hospital records showed she was admitted for hallucinations and confusion after being started on a full dose of Valtrex despite ESRD. The hospital documented toxic metabolic encephalopathy due to the high dose of Valtrex in the setting of end stage renal disease, and her encephalopathy slowly resolved after the medication was stopped. Later documentation noted she had been recently hospitalized for altered mental status after receiving full-dose Valtrex, which improved after discontinuation.
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